DC Moore Gallery specializes in Contemporary and American 20th-century art. The gallery represents a lively mix of contemporary artists including Eric Aho, David Driskell, Janet Fish, Mary Frank, Mark Innerst, Yvonne Jacquette, Valerie Jaudon, Joyce Kozloff, Robert Kushner, Whitfield Lovell, Duane Michals, Carrie Moyer, Claire Sherman, Barbara Takenaga, Darren Waterston, Alexi Worth, and Jimmy Wright. The gallery also represents the estates of Romare Bearden, Isabel Bishop, Roger Brown, Charles Burchfield, Robert De Niro, Sr., Jacob Lawrence, George Tooker, and Jane Wilson. The gallery handles artwork from early 20th-century movements including American Modernism, African American Art, Social Realism, Regionalism, Magic Realism, and Precisionism by such artists as Milton Avery, Thomas Hart Benton, Oscar Bluemner, Paul Cadmus, Arthur Dove, Marsden Hartley, Edward Hopper, Rockwell Kent, John Marin, Reginald Marsh, PaJaMa, Fairfield Porter, Ben Shahn, and others.

The DC Moore Gallery staff is dedicated to providing expertise, guidance, and personal attention to both the beginning and established collector, as well as working with museum, corporate, and other art professionals in both the acquisition and sale of works of art. DC Moore Gallery is a member of the Art Dealers Association of America.