Isca Greenfield-Sanders (American, b.1978) is a painter, whose work fuses photography, watercolor, drawing, and oils to create layered images that blur the boundaries between abstraction and figuration. A native of New York City, Greenfield-Sanders received a BA in visual arts and math from Brown University in 2000. She then accepted a position as the visiting artist at the American Academy in Rome, and has since had numerous solo and group exhibitions throughout the United States and Europe.

Through her work, Greenfield-Sanders explores themes of nostalgia, memory, and American ideals, using a combination of digital media and traditional techniques to create oil paintings out of vintage photographs. To make her images, she first scans and edits the photo, prints it onto a piece of paper, and then paints over it with watercolor and colored pencil. The final result is a composite of square tiles, with subjects ranging from soccer field and beach scenes to Korean War parachute paintings.

Her pieces are included in the collections of the Guggenheim Museum in New York, the Museum Morsbroich in Germany, the Museum of Fine Arts, Houston, and the Progressive Collection in Ohio, among others. Articles on her work have appeared in publications such as New York Magazine, Elle Décor, and Vanity Fair.

She currently lives and works in New York.